I'm a paragraph. Click here to add your own text and edit me. It’s easy. Just click “Edit Text” or double click me to add your own content and make changes to the font. I’m a great place for you to tell a story and let your users know a little more about you.
I'm a paragraph. Click here to add your own text and edit me. It’s easy. Just click “Edit Text” or double click me to add your own content and make changes to the font. I’m a great place for you to tell a story and let your users know a little more about you.
I'm a paragraph. Click here to add your own text and edit me. It’s easy. Just click “Edit Text” or double click me to add your own content and make changes to the font. I’m a great place for you to tell a story and let your users know a little more about you.
Complement C3 and autophagy keep the Beta cell alive.
Toledo M, Singh R. Cell Metabolism. 2019 Jan 8;29(1):4-6
Autophagy regulates the liver clock and glucose metabolism by degrading CRY1.
Toledo M, Batista-Gonzalez A, Merheb E, Aoun ML, Tarabra E, Feng D, Sarparanta J, Merlo P, Botre F, Schwartz GJ, Pessin JE, Singh R. Cell Metabolism. 2018 Aug 7;28(2):268-281
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Blocking p62/SQSTM1-dependent SMN degradation ameliorates Spinal Muscular Atrophy disease phenotypes.
Rodriguez-Muela N, Parkhitko A, Grass T, Gibbs RM, Norabuena EM, Perrimon N, Singh R, Rubin LL. Journal of Clinical Investigation. 2018 Jul 2;128(7):3008-3023
System-wide benefits of intermeal fasting by autophagy.
Martinez-Lopez N, Tarabra E, Toledo E, Garcia-Macia M, Sahu S, Coletto L, Batista-Gonzalez A, Barzilai N, Pessin JE, Schwartz GJ, Kersten S, Singh R. Cell Metabolism. 2017 Dec 5;26(6):856-871
Highlighted: Nature Reviews in Endocrinology
Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.
Ito K, Turcotte R, Cui J, Zimmerman SE, Pinho S, Mizoguchi T, Arai F, Runnels JM, Alt C, Teruya-Feldstein J, Mar JC, Singh R, Suda T, Lin CP, Frenette PS, Ito K. Science. 2016 Dec 2;354(6316):1156-1160
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ, … Singh R, … Zughaier SM. Autophagy. 2016;12(1):1-222
Autophagy in the CNS and periphery coordinate lipophagy and lipolysis in the brown adipose tissue and liver.
Martinez-Lopez N, Garcia-Macia M, Sahu S, Athonvarangkul D, Liebling E, Merlo P, Cecconi F, Schwartz GJ, Singh R. Cell Metabolism. 2016; 23: 113-127
Autophagy and lipid droplets in the liver.
Martinez-Lopez N, Singh R. Annual Review of Nutrition. 2015; 35: 215-237
Loss of the RNA polymerase III repressor MAF1 confers obesity resistance.
Bonhoure N, Byrnes A, Moir RD, Hodroj W, Preitner F, Praz V, Marcelin G, Chua SC Jr, Martinez-Lopez N, Singh R, Moullan N, Auwerx J, Willemin G, Shah H, Hartil K, Vaitheesvaran B, Kurland I, Hernandez N, Willis IM. Genes & Development. 2015; 29: 934-947
Autophagy proteins regulate ERK phosphorylation.
Martinez-Lopez N, Athonvarangkul D, Mishall P, Sahu S, Singh R. Nature Communications. 2013; 4: 2799
Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development.
Martinez-Lopez N, Athonvarangkul D, Sahu S, Coletto L, Zong H, Bastie CC, Pessin JE, Schwartz GJ, Singh R. EMBO Reports. 2013; 14(9): 795-803
Mapping autophagy onto your metabolic radar.
Yamada E, Singh R. Diabetes. 2012; 61: 272-280
Loss of autophagy in hypothalamic POMC neurons impairs lipolysis.
Kaushik S, Arias E, Kwon H, Martinez-Lopez N, Sahu S, Schwartz GJ, Pessin JE, Singh R. EMBO Reports. 2012; 13(3): 258-265
Comment: Rubinsztein DC. Autophagy-alias self-eating-appetite and ageing. EMBO Reports 2012;13(3):173-174
Issue Cover
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Autophagy in the cellular energetic balance.
Singh R, Cuervo AM. Cell Metabolism. 2011; 13: 495-504
Cell Metabolism: Top 10 Reviews, 2005-2014, as chosen by the readers
Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance.
Kaushik S, Rodriguez-Navarro, JA, Arias E, Kiffin R, Sahu S, Schwartz GJ, Cuervo AM, Singh R. Cell Metabolism. 2011; 14: 173-183
Featured: The Scientist magazine, The Los Angeles Times, Fox News, EurekAlert.com, Jay Leno, National Public Radio
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Nuclear factor κB up-regulation of CCAAT/enhancer-binding protein β mediates hepatocyte resistance to tumor necrosis factor α toxicity.
Wang Y, Singh R, Xiang Y, Greenbaum LE, Czaja MJ. Hepatology. 2010; 52: 2118-2126
Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress.
Wang Y*, Singh R*, Xiang Y, Czaja MJ. Hepatology. 2010; 52: 266-277
Autophagy regulates adipose mass and differentiation.
Singh R, Xiang Y, Wang Y, Baikati K, Cuervo AM, Luu YK, Tang Y, Pessin JE, Schwartz GJ, Czaja MJ. Journal of Clinical Investigation. 2009; 119(11): 3329-3339
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Autophagy regulates lipid metabolism.
Singh R,* Kaushik S,* Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo, AM, Czaja, MJ. Nature. 2009; 458: 1131-1135. *co-first authors
Nature News and Views: Zechner R, Madeo F. Cell biology: Another way to get rid of fat. Nature 2009; 458: 1118-1119
Preview: Weidberg H, Shvets E, Elazar Z. Lipophagy: Selective catabolism designed for lipids. Dev. Cell 2009; 16: 628-30
Hepatology Elsewhere: Kersten S, Müller M. Dropping liver fat droplets. Hepatology 2009; 50: 645-647
Featured in communication media: ABC, BBC, Discover Magazine, Science Central, Science Daily, Washington Post
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Differential effects of JNK1 and JNK2 inhibition on insulin resistance and steatohepatitis.
Singh R, Wang Y, Xiang Y, Tanaka KE, Gaarde WA, and Czaja MJ. Hepatology. 2009; 49: 87-96
Comment: c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. Kodama Y, Brenner DA. Hepatology 2009; 49: 6-8
