Complement C3 and autophagy keep the Beta cell alive. 

Toledo M, Singh R.  Cell Metabolism2019 Jan 8;29(1):4-6

 

Autophagy regulates the liver clock and glucose metabolism by degrading CRY1.

Toledo M, Batista-Gonzalez A, Merheb E, Aoun ML, Tarabra E, Feng D, Sarparanta J, Merlo P, Botre F, Schwartz GJ, Pessin JE, Singh R.  Cell Metabolism2018 Aug 7;28(2):268-281

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Blocking p62/SQSTM1-dependent SMN degradation ameliorates Spinal Muscular Atrophy disease phenotypes.
Rodriguez-Muela N, Parkhitko A, Grass T, Gibbs RM, Norabuena EM, Perrimon N, Singh R, Rubin LL.  Journal of Clinical Investigation2018 Jul 2;128(7):3008-3023  

 

System-wide benefits of intermeal fasting by autophagy.
Martinez-Lopez N, Tarabra E, Toledo E, Garcia-Macia M, Sahu S, Coletto L, Batista-Gonzalez A, Barzilai N, Pessin JE, Schwartz GJ, Kersten S, Singh R.  Cell Metabolism2017 Dec 5;26(6):856-871

Highlighted: Nature Reviews in Endocrinology  

 

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.
Ito K, Turcotte R, Cui J, Zimmerman SE, Pinho S, Mizoguchi T, Arai F, Runnels JM, Alt C, Teruya-Feldstein J, Mar JC, Singh R, Suda T, Lin CP, Frenette PS, Ito K.  Science2016 Dec 2;354(6316):1156-1160

 

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ, … Singh R, … Zughaier SM.  Autophagy2016;12(1):1-222

 

Autophagy in the CNS and periphery coordinate lipophagy and lipolysis in the brown adipose tissue and liver.
Martinez-Lopez N, Garcia-Macia M, Sahu S, Athonvarangkul D, Liebling E, Merlo P, Cecconi F, Schwartz GJ, Singh R.  Cell Metabolism2016; 23: 113-127 

Autophagy and lipid droplets in the liver. 

Martinez-Lopez N, Singh R.  Annual Review of Nutrition2015; 35: 215-237 

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance.
Bonhoure N, Byrnes A, Moir RD, Hodroj W, Preitner F, Praz V, Marcelin G, Chua SC Jr, Martinez-Lopez N, Singh R, Moullan N, Auwerx J, Willemin G, Shah H, Hartil K, Vaitheesvaran B, Kurland I, Hernandez N, Willis IM.  Genes & Development2015; 29: 934-947 

 

Autophagy proteins regulate ERK phosphorylation.
Martinez-Lopez N, Athonvarangkul D, Mishall P, Sahu S, Singh R.  Nature Communications2013; 4: 2799 

 

Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development.
Martinez-Lopez N, Athonvarangkul D, Sahu S, Coletto L, Zong H, Bastie CC, Pessin JE, Schwartz GJ, Singh R.  EMBO Reports2013; 14(9): 795-803

 

Mapping autophagy onto your metabolic radar.
Yamada E, Singh R.  Diabetes2012; 61: 272-280  

 

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis.
Kaushik S, Arias E, Kwon H, Martinez-Lopez N, Sahu S, Schwartz GJ, Pessin JE, Singh R.  EMBO Reports. 2012; 13(3): 258-265 
Comment: Rubinsztein DC. Autophagy-alias self-eating-appetite and ageing. EMBO Reports 2012;13(3):173-174   
Issue Cover  
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Autophagy in the cellular energetic balance. 
Singh R, Cuervo AM.  Cell Metabolism2011; 13: 495-504 
Cell Metabolism: Top 10 Reviews, 2005-2014, as chosen by the readers 

Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance. 
Kaushik S, Rodriguez-Navarro, JA, Arias E, Kiffin R, Sahu S, Schwartz GJ, Cuervo AM, Singh R.   Cell Metabolism2011; 14: 173-183
Featured: The Scientist magazine, The Los Angeles Times, Fox News, EurekAlert.com, Jay Leno, National Public Radio  
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Nuclear factor κB up-regulation of CCAAT/enhancer-binding protein β mediates hepatocyte resistance to tumor necrosis factor α toxicity.
Wang Y, Singh R, Xiang Y, Greenbaum LE, Czaja MJ.   Hepatology2010; 52: 2118-2126 

Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress.
Wang Y*, Singh R*, Xiang Y, Czaja MJ.   Hepatology2010; 52: 266-277

Autophagy regulates adipose mass and differentiation. 
Singh R, Xiang Y, Wang Y, Baikati K, Cuervo AM, Luu YK, Tang Y, Pessin JE, Schwartz GJ, Czaja MJ.  Journal of Clinical Investigation2009; 119(11): 3329-3339
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Autophagy regulates lipid metabolism. 
Singh R,* Kaushik S,* Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo, AM, Czaja, MJ.  Nature. 2009; 458: 1131-1135. *co-first authors  
Nature News and Views: Zechner R, Madeo F. Cell biology: Another way to get rid of fat. Nature 2009; 458: 1118-1119   
Preview: Weidberg H, Shvets E, Elazar Z. Lipophagy: Selective catabolism designed for lipids. Dev. Cell 2009; 16: 628-30 
Hepatology Elsewhere: Kersten S, Müller M. Dropping liver fat droplets. Hepatology 2009; 50: 645-647
Featured in communication media: ABC, BBC, Discover Magazine, Science Central, Science Daily, Washington Post
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Differential effects of JNK1 and JNK2 inhibition on insulin resistance and steatohepatitis.
Singh R, Wang Y, Xiang Y, Tanaka KE, Gaarde WA, and Czaja MJ.   Hepatology. 2009; 49: 87-96
Comment: c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. Kodama Y, Brenner DA. Hepatology 2009; 49: 6-8

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